Accessed: February 20, 2020. Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Mann G, Attarbaschi A, Schrappe M, De Lorenzo P, Peters C, Hann I, et al. What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? 1996 Mar. Leuk Lymphoma. The aim of remission induction is to kill the leukaemia cells in your bone marrow, restore the balance of cells in your blood, and relieve your symptoms. [Medline]. Consolidation treatment of adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after autologous bone marrow transplantation. Blood. [90] : NCCN guidelines note that diagnosis of ALL generally requires the following Leukemia. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. A. Möricke, A. Reiter, M. Zimmermann, H. Gadner, M. Stanulla, M. Dördelmann, et al.Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95 Weiss M, Maslak P, Feldman E, Berman E, Bertino J, Gee T, et al. Fielding AK, Rowe JM, Buck G, Foroni L, Gerrard G, Litzow MR, et al. Available at https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm574058.htm. 2014 Jan. 99 (1):111-5. The GIMEMA ALL 0183 trial: analysis of 10-year follow-up. Jeha S, Gaynon PS, Razzouk BI, Franklin J, Kadota R, Shen V, et al. Central nervous system disease in acute lymphoblastic leukemia. 2010 Aug 1. Reshmi SC, Harvey RC, Roberts KG, et al. [Medline]. Biol Blood Marrow Transplant. [Medline]. [Medline]. [Full Text]. Bethesda, Maryland: National Cancer Institute; 2006. 2017 Feb 1. 103(12):4396-407. 56:44-51. Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses. If you have a type of leukaemia called Philadelphia chromosome-positive acute lymphoblastic leukaemia (which affects around 20 to 30% of people with acute lymphoblastic leukaemia), you'll also be given a medicine called imatinib. N Engl J Med. Treatment of adult acute lymphoblastic leukemia. 2004. You'll probably need regular blood transfusions because your blood will not contain enough healthy blood cells. Consider echocardiogram or cardiac scan, especially in patients with prior cardiac history and prior anthracycline exposure or clinical symptoms suggestive of cardiac dysfunction. Hunault M, Harousseau JL, Delain M, Truchan-Graczyk M, Cahn JY, Witz F, et al. 2008 Apr 10. Get information about risk factors, signs, diagnosis, molecular features, survival, risk-based treatment assignment, and induction and postinduction therapy for children and adolescents with newly diagnosed and recurrent ALL. 1987 Jun. Blood. The consolidation phase involves regular injections of chemotherapy medicine. 92(3):665-72. 30:125-9. [Medline]. The Leukemia Treatment Program for children and teenagers at the Hyundai Cancer Institute at CHOC is dedicated to providing patients with the most advanced, pediatric leukemia treatment available. Ronald A Sacher, MBBCh, FRCPC, DTM&H is a member of the following medical societies: American Association for the Advancement of Science, American Association of Blood Banks, American Clinical and Climatological Association, American Society for Clinical Pathology, American Society of Hematology, College of American Pathologists, International Society of Blood Transfusion, International Society on Thrombosis and Haemostasis, Royal College of Physicians and Surgeons of CanadaDisclosure: Nothing to disclose. Been approved for the treatment of adult ALL in first bone marrow relapse: results of acute lymphoblastic leukemia treatment guideline Medical Research randomized... Merchant a, Merin N, Yagasaki F, Thomas D, et.! Wiernik PH, Richards SM, et al pathologist may use flow cytometry in the UK Clinical. On chemotherapy they work in treating and possibly curing acute leukaemia have restricted growth! 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